PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 10274152

Searching computer databases from your office.

S Bader·C Harbert·A Linton
View original source ↗Export metadata ↓

Abstract

Microcomputers, and a new generation of on-line systems designed for the end-user, now make it possible for physicians to search MEDLINE and a variety of other databases in the convenience of their offices or homes. This article explains some basics of online searching, describes capabilities and options to consider when selecting a system, and identifies hardware and software needed to adapt a micro for online searching. A chart comparing system features and costs, and providing information on where to go for more information is also included.

Explore related subjects

ComputersInformation ServicesMicrocomputersOnline SystemsPhysicians' OfficesUnited StatesJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

S Bader, C Harbert, A Linton. 1985. Searching computer databases from your office.. https://pubmed.ncbi.nlm.nih.gov/10274152/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2000

Avatars in space.

Explore the source record for details and available documents.

Computers↗
PubMed2000

Structure-based inhibitor design.

Time and costs associated with the discovery of new drugs have been significantly reduced by enzyme structure-based approaches to the discovery of new chemotherapeutic agents. However, fundamental components of the overall approach continue to rely on technologies which, by their nature, involve relatively random processes (i.e., combinatorial chemistry and high-throughput screening). Thus, the efficiency of the drug discovery process potentially could be further improved through better use of structural information. In this regard, three-dimensional structures of enzymes are now being solved at high resolution and/or in conformations that provide data that should be more useful for inhibitor design or discovery. Scientists are beginning to appreciate the importance of water as a possible competitor of inhibitors for binding to target enzymes. New computational algorithms are improving the efficiency of identifying flexible inhibitors from among the large numbers of compounds in chemical databases. Also, tools of molecular genetics together with structures of target enzymes are likely to be used more frequently in dealing with the development of resistance to novel chemotherapeutic agents. Instead of detailing success stories in structure-based drug discovery, the following article considers how future efforts to discover or design new drugs may increasingly rely on information about molecular targets and less on data acquired via approaches involving random methodologies.

Computers↗