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PubMed · 10327849

[Renal crisis in systemic sclerosis].

G Haugeberg·R Bie·R Orstavik
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Abstract

Systemic sclerosis is a rare connective tissue disorder, potentially affecting several internal organs. Renal disease is seen in 10-40% of the cases, while autopsy studies have shown interstitial renal changes in as many as 80%. Renal involvement is clinically divided into two separate forms; chronic and acute nephritis. Acute nephritis in a patient suffering from systemic sclerosis is termed renal chrisis, and is associated with high morbidity and mortality. Renal crisis in systemic sclerosis is discussed based on a case report and a review of the literature. Treatment with ACE-inhibitors has dramatically improved the prognosis of this complication. Careful surveillance of patients at risk, especially patients with the diffuse type of systemic sclerosis and showing antibodies against RNA-polymerase, as well as early treatment is considered important for the outcome.

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Acute Kidney InjuryAdultAntibodies, AntinuclearAutopsyFatal OutcomeFemaleHumansImmunohistochemistryKidneyKidney GlomerulusNephritis, InterstitialScleroderma, SystemicCase ReportsEnglish AbstractJournal Article

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G Haugeberg, R Bie, R Orstavik. 1999-04-10. [Renal crisis in systemic sclerosis].. https://pubmed.ncbi.nlm.nih.gov/10327849/

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