PubMed · 103418
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M S Hansen. 1978. Application site for nitroglycerin ointment.. https://doi.org/10.1016/0002-9149(78)90707-5
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Dimethylsulfoxide (DMSO) was shown to inhibit the proliferation of several B cell lines including Raji, Daudi, and SKW6-CL4 but the mechanisms involved in this growth arrest are still unclear. We show that in 7TD1 mouse hybridoma cells a DMSO-induced reversible G1 arrest involves inactivation of Rb kinases, cyclin D2/CDK4 and cyclin E/CDK2. This occurs by at least three distinct mechanisms. Inhibition of cyclin D2 neosynthesis leads to a dramatic decrease of cyclinD2/CDK4 complexes. This in turn enables the redistribution of p27[KIP1] from cyclin D2/CDK4 to cyclin E/CDK2 complexes. In addition, the simultaneous accumulation of p21[CIP1] entails increasing association with cyclin D3/CDK4 and cyclin E/CDK2. Thus, p21[CIP1] and p27[KIP1], act in concert to inhibit cyclin E/CDK2 activity which, together with CDK4 inactivation, confers a G1-phase arrest.
A field study was conducted between May and October 1995 to examine the efficacy of 0.5 mg/kg ivermectin pour-on on parasitic gastroenteritis of set-stocked calves at turnout and 6 weeks later. A treated group of 10 calves was compared with a separately grazed group of 10 non-treated calves; 14 calves were used as tracer animals. Initial infection levels appeared to be very low in both groups and faecal egg counts, pasture larval counts, serum pepsinogen levels and optical density (OD) values of an ELISA with a specific recombinant antigen for Cooperia oncophora remained low for 4 months. Thereafter, a rapid build up of gastrointestinal nematode infections occurred in both groups.