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PubMed · 10346966

Two auronols from Pseudolarix amabilis.

X C Li·H N ElSohly·A C Nimrod·A M Clark
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Abstract

Two new auronols, amaronols A (1) and B (2), were isolated from the bark of Pseudolarix amabilis, along with pseudolaric acid B (3), pseudolaric acid C (4), demethoxydeacetoxy-pseudolaric acid B (5), pseudolaric acid B-beta-D-glucoside (6), pseudolaric acid A-beta-D-glucoside (7), and myricetin (8). The structures of amaronols A and B were established by spectral data interpretation as 2,4,6-trihydroxy-2-[(3',4',5'-trihydroxyphenyl) methyl]-3(2H)-benzofuranone and 2,4,6-trihydroxy-2-[(3', 5'-dihydroxy-4'-methoxyphenyl) methyl]-3(2H)-benzofuranone, respectively. Antimicrobial testing results of the eight compounds indicated that only pseudolaric acid B was active against Candida albicans (MIC, 3.125 microg/mL; MFC, 6.25 microg/mL), while myricetin was marginally active against Trichophyton mentagrophytes (MIC, 50 microg/mL).

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Antifungal AgentsBenzofuransCandida albicansChromatography, High Pressure LiquidCycadopsidaDrugs, Chinese HerbalMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsPhenolsSpectrophotometry, UltravioletTrichophytonJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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X C Li, H N ElSohly, A C Nimrod, A M Clark. 1999. Two auronols from Pseudolarix amabilis.. https://doi.org/10.1021/np980469w

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