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PubMed · 10378018

Plasma lipoprotein (a) concentrations in hypothyroid, euthyroid and hyperthyroid subjects.

C Erem·O Değer·M Bostan·A Orem·M Sönmez·S Ulusoy·M Telatar
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Abstract

OBJECTIVE: Alterations of the lipid profile are a well known phenomenon in thyroid dysfunction. Thyroid hormones regulate lipid metabolism through various mechanisms, but a key role is played by the LDL receptor pathway. Thyroid hormone influence on lipoprotein (a) [Lp(a)] metabolism is known. METHODS AND RESULTS: Therefore we studied Lp(a) concentrations in a group of 16 hypothyroid patients and in a group of 22 hyperthyroid patients. Twenty-six euthyroid subjects were used as a control group. Plasma Lp(a) concentrations in hyperthyroid patients (23.2 +/- 28.1 mg/dl) were significantly lower than those of the hypothyroid patients (27.1 +/- 19.2, p < 0.05). There were negative correlations between plasma Lp(a) concentrations and total T4 levels in patients with hyperthyroidism and hypothyroidism (r: -0.49, p < 0.05; r: -0.40, p < 0.05, respectively). Also, decreased HDL-C levels, increased LDL-C, total cholesterol and apo B levels in the hypothyroid patients according to euthyroid subjects were observed (p < 0.05). Decreased LDL-C levels, increased HDL-C and apo Al levels in the hyperthyroid patients according to euthyroid subjects were determined (p < 0.05). CONCLUSIONS: It was concluded that plasma Lp(a) concentrations increase in hypothyroid patients and the observed relationships between thyroid status and Lp(a) levels can be explained by impaired catabolism of apo B and Lp(a) in hypothyroidism.

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AdultAgedApolipoproteins BCholesterolCholesterol, HDLCholesterol, LDLFemaleHumansHyperthyroidismHypothyroidismLipoprotein(a)MaleMiddle AgedReference ValuesThyroid Function TestsThyroxineJournal Article

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C Erem, O Değer, M Bostan, A Orem, M Sönmez, S Ulusoy, M Telatar. 1999. Plasma lipoprotein (a) concentrations in hypothyroid, euthyroid and hyperthyroid subjects.. https://pubmed.ncbi.nlm.nih.gov/10378018/

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