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PubMed · 10431029

Leptin in renal failure.

C S Mantzoros
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Abstract

Leptin, an adipocyte-derived hormone, signals to the brain information on the amount of energy stored in adipose tissue and regulates energy homeostasis. In addition, leptin has been implicated in the regulation of neuroendocrine function, growth, hematopoiesis, and immune regulation. Plasma leptin is cleared by the kidney, and thus, leptin levels are elevated in hemodialysis patients. Whether the elevated leptin levels in hemodialysis patients contribute to the pathophysiology of the clinical manifestations of renal failure in humans remains to be conclusively shown in the future.

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Carrier ProteinsHumansKidneyKidney Failure, ChronicLeptinProteinsReceptors, Cell SurfaceReceptors, LeptinRenal DialysisJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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C S Mantzoros. 1999. Leptin in renal failure.. https://doi.org/10.1016/s1051-2276(99)90048-1

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