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PubMed · 10451480

Do HPV-negative cervical carcinomas exist?--revisited.

C S Herrington
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Abstract

There has been considerable debate regarding the existence of HPV-negative cervical carcinoma. In this issue of the journal, using well-controlled methodology, Walboomers et al. demonstrate that HPV DNA is present in almost all invasive carcinomas in a large multinational study. This indicates that HPV-negative carcinoma is extremely uncommon, if it exists at all. It also implies that HPV testing, if optimally applied, is capable of a sensitivity approaching 100 per cent. This has significant implications for cervical screening.

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DNA, ViralFemaleHumansIn Situ HybridizationPapillomaviridaePolymerase Chain ReactionSensitivity and SpecificityUterine Cervical NeoplasmsVaginal SmearsCommentEditorial

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C S Herrington. 1999. Do HPV-negative cervical carcinomas exist?--revisited.. https://doi.org/10.1002/(sici)1096-9896(199909)189%3A1%3C1%3A%3Aaid-path432%3E3.0.co%3B2-p

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