Glutamate transport and renal function.

T C Welbourne; J C Matthews

doi:10.1152/ajprenal.1999.277.4.f501

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Glutamate transport and renal function.

T C Welbourne·J C Matthews

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Abstract

Brush border gamma-glutamyltransferase-glutaminase activity and the high-affinity glutamate transporter EAAC1 function as a unit in generating and transporting extracellular glutamate into proximal tubules as a signal that modulates intracellular glutamine/glutamate metabolism, paracellular permeability, and urinary acidification. The reported presence of a second glutamate transporter, GLT1, on the antiluminal tubule surface points to specific functional roles for each subtype in physiological and pathophysiological processes.

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ATP-Binding Cassette Transporters Amino Acid Transport System X-AG Animals Biological Transport Carrier Proteins Glutamate Plasma Membrane Transport Proteins Glutamic Acid Kidney Kidney Tubules, Proximal Symporters gamma-Glutamyltransferase Journal Article Review

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T C Welbourne, J C Matthews. 1999. Glutamate transport and renal function.. https://doi.org/10.1152/ajprenal.1999.277.4.f501

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