Vertebrate endoderm development.

J M Wells; D A Melton

doi:10.1146/annurev.cellbio.15.1.393

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PubMed · 10611967

Vertebrate endoderm development.

J M Wells·D A Melton

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Abstract

Endoderm, one of the three principal germ layers, contributes to all organs of the alimentary tract. For simplicity, this review divides formation of endodermal organs into four fundamental steps: (a) formation of endoderm during gastrulation, (b) morphogenesis of a gut tube from a sheet of cells, (c) budding of organ domains from the tube, and (d) differentiation of organ-specific cell types within the growing buds. We discuss possible mechanisms that regulate how undifferentiated endoderm becomes specified into a myriad of cell types that populate the respiratory and gastrointestinal tracts.

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Animals Body Patterning Cell Differentiation Cell Lineage Digestive System Endoderm Humans Vertebrates Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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J M Wells, D A Melton. 1999. Vertebrate endoderm development.. https://doi.org/10.1146/annurev.cellbio.15.1.393

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