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PubMed · 10614499

Specific cell-mediated immunity in fish.

T Nakanishi·K Aoyagi·C Xia·J M Dijkstra·M Ototake
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Abstract

This review describes the fish immune system, focusing on specific cell-mediated immunity. Specific in vivo cell-mediated immune responses have been shown by allograft rejection, graft-versus-host reaction (GVHR) and delayed hypersensitivity reaction (DTH). Recent in vitro studies also showed specific cell-mediated cytotoxicity against allogeneic target cells. These in vivo and in vitro experiments strongly suggest the presence of cytotoxic T cells in fishes. Also described are current studies on shark and trout MHC class I polymorphism and function that demonstrate strong similarities between fish and mammals.

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AnimalsFishesGenes, MHC Class IGraft RejectionGraft vs Host DiseaseHypersensitivity, DelayedImmunity, CellularOncorhynchus mykissPolymorphism, GeneticSharksJournal ArticleReview

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BibTeXRIS

T Nakanishi, K Aoyagi, C Xia, J M Dijkstra, M Ototake. 1999-12-15. Specific cell-mediated immunity in fish.. https://doi.org/10.1016/s0165-2427(99)00122-1

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