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PubMed · 10618487

The transporter associated with antigen processing TAP: structure and function.

B Lankat-Buttgereit·R Tampé
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Abstract

The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.

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AntigensCarrier ProteinsDiseaseEndoplasmic ReticulumGene Expression RegulationHumansStructure-Activity RelationshipSubstrate SpecificityJournal ArticleReview

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B Lankat-Buttgereit, R Tampé. 1999-12-31. The transporter associated with antigen processing TAP: structure and function.. https://doi.org/10.1016/s0014-5793(99)01676-2

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