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Molecular computation: RNA solutions to chess problems.

D Faulhammer·A R Cukras·R J Lipton·L F Landweber
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Abstract

We have expanded the field of "DNA computers" to RNA and present a general approach for the solution of satisfiability problems. As an example, we consider a variant of the "Knight problem," which asks generally what configurations of knights can one place on an n x n chess board such that no knight is attacking any other knight on the board. Using specific ribonuclease digestion to manipulate strands of a 10-bit binary RNA library, we developed a molecular algorithm and applied it to a 3 x 3 chessboard as a 9-bit instance of this problem. Here, the nine spaces on the board correspond to nine "bits" or placeholders in a combinatorial RNA library. We recovered a set of "winning" molecules that describe solutions to this problem.

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AlgorithmsCombinatorial Chemistry TechniquesComputational BiologyDNAGames, ExperimentalOligodeoxyribonucleotidesPolymerase Chain ReactionRNARibonucleasesCommentJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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D Faulhammer, A R Cukras, R J Lipton, L F Landweber. 2000-02-15. Molecular computation: RNA solutions to chess problems.. https://doi.org/10.1073/pnas.97.4.1385

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