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PubMed · 10701921

LC method development for ibuprophen and validation in different pharmaceuticals.

A I Gasco-Lopez·R Izquierdo-Hornillos·A Jimenez
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Abstract

An isocratic LC method for the simultaneous determination of ibuprophen (IBU) and its degradation product (4-isobutylacetophenone) has been developed and validated for different pharmaceuticals (sachets, tablets and gels). The chromatographic separation was achieved with phosphoric acid solution (pH 3.2)-acetonitrile (50:50, v/v) as mobile phase, a Hypersil C18 column and UV detection at 254 nm. In all cases, sample preparation was required before HPLC analysis.

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Anti-Inflammatory Agents, Non-SteroidalChromatography, LiquidIbuprofenQuality ControlReproducibility of ResultsJournal Article

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A I Gasco-Lopez, R Izquierdo-Hornillos, A Jimenez. 1999. LC method development for ibuprophen and validation in different pharmaceuticals.. https://doi.org/10.1016/s0731-7085(99)00127-2

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