A solution-phase combinatorial synthesis of selective dopamine D4 ligands.

J P Williams; K Lavrador

doi:10.2174/1386207003327710

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PubMed · 10702613

A solution-phase combinatorial synthesis of selective dopamine D4 ligands.

J P Williams·K Lavrador

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Abstract

Utilizing combinatorial synthesis and a preparative LC-MS automated chromatography system we have prepared and purified a library of 4-[2-(1,2,4-oxadiazolyl)]piperidines that were designed to be novel and selective dopamine D4 ligands. In one round of synthesis we identified N-4-chlorobenzyl-4-[2-(3-(2-thienyl)-1,2, 4-oxadiazolyl)]piperidine with a Kd of 5 nM for the human D4 receptor.

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Combinatorial Chemistry Techniques Dopamine Agents Humans Ligands Receptors, Dopamine D2 Receptors, Dopamine D4 Solutions Journal Article

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J P Williams, K Lavrador. 2000. A solution-phase combinatorial synthesis of selective dopamine D4 ligands.. https://doi.org/10.2174/1386207003327710

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