Solid-phase synthesis of cyclic imides.

D R Barn; J R Morphy

doi:10.1021/cc980024q

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Solid-phase synthesis of cyclic imides.

D R Barn·J R Morphy

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Abstract

A cyclative cleavage strategy for the synthesis of cyclic imides on a polystyrene resin is described. After optimization of the cleavage conditions, a small array of succinimides and phthalimides was synthesized. The methodology was then applied to a drug discovery project, in which it was used to synthesize a new class of delta-opioid receptor ligand by both automated and manual methods.

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Combinatorial Chemistry Techniques Drug Design Imides Indicators and Reagents Molecular Structure Polystyrenes Resins, Plant Structure-Activity Relationship Journal Article

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D R Barn, J R Morphy. Solid-phase synthesis of cyclic imides.. https://doi.org/10.1021/cc980024q

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