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PubMed · 10798248

Analgesic principle from Abutilon indicum.

M Ahmed·S Amin·M Islam·M Takahashi·E Okuyama·C F Hossain
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Abstract

Bioactivity guided isolation of Abutilon indicum yielded eugenol [4-allyl-2-methoxyphenol], which was found to possess significant analgesic activity. At doses of 10, 30, and 50 mg/kg body weight, eugenol exhibited 21.30 (p < 0.05), 42.25 (p < 0.01) and 92.96% (p < 0.001) inhibition of acetic acid induced writhing in mice. At a dose of 50 mg/kg body weight, eugenol showed 33.40% (p < 0.05) prolongation of tail flicking time determined by the radiant heat method.

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AcetatesAnalgesicsAnimalsChromatography, Thin LayerEugenolHot TemperatureMaleMiceOils, VolatilePain MeasurementPlants, MedicinalRatsJournal ArticleResearch Support, Non-U.S. Gov't

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M Ahmed, S Amin, M Islam, M Takahashi, E Okuyama, C F Hossain. 2000. Analgesic principle from Abutilon indicum.. https://pubmed.ncbi.nlm.nih.gov/10798248/

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