Genetic and environmental contributions.

M D Jensen

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PubMed · 10812932

Genetic and environmental contributions.

M D Jensen

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Abstract

There is a remarkable variability in insulin action in humans. Depending upon the definition of the insulin resistance syndrome, different inheritability/environmental influences on insulin action are reported. The environmental contributions to insulin resistance appear to account for approximately 50% of this syndrome. Obese and sedentary insulin-resistant individuals can see dramatic improvement in insulin sensitivity with weight reduction and fitness training. The degree to which obesity is determined by genetic influences will have a substantial impact on insulin resistance in the Western populations. Familial components also appear to account for approximately 50% of the variation and insulin action (as commonly defined by glucose metabolic effects).

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Cluster Analysis Environment Glucose Tolerance Test Humans Insulin Insulin Resistance Obesity Journal Article Review

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M D Jensen. 2000. Genetic and environmental contributions.. https://pubmed.ncbi.nlm.nih.gov/10812932/

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