PubMed · 10866570
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F Kainberger, E Ranschaert, S Achenbach. 2000. [Glossary].. https://doi.org/10.1007/s001170050687
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MOTIVATION: Malaria, caused by Plasmodium parasites, imposes a significant public health burden. While Plasmodium falciparum remains the primary target of elimination strategies due to its high mortality rate, lesser-known species such as P. malariae, P. vivax, and P. knowlesi continue to contribute to substantial human morbidity. Genomic approaches, including whole-genome sequencing, offer powerful tools for understanding the biology, transmission, and emerging drug resistance of these neglected Plasmodium species. However, there is an urgent need for informatic tools to summarize and visualize the high-dimensional and complex genomic data generated. RESULTS: We developed Malaria-GENOMAP, a user-friendly web-based tool, which integrates genomic variant data, such as allele frequencies, with geographical maps and chromosome-wide to gene views for in-depth exploration. The tool includes variation from P. knowlesi (n = 139), P. malariae (n = 158), P. ovale curtisi (n = 36), P. ovale wallikeri (n = 47), P. simium (n = 38), and P. vivax (n = 1359). It enables the investigation of population structure, geographic associations of mutations, and putative drug resistance markers, offering valuable insights for malaria control efforts. AVAILABILITY AND IMPLEMENTATION: Malaria-GENOMAP is available online at https://genomics.lshtm.ac.uk/malaria-genomaps.
The need to implement improved teaching methods in clinical pharmacology is critically important for health care globally. This need is driven by the overwhelming amount of information currently available on appropriate drug usage, by a proliferation of new biotechnology-derived pharmacologic agents, and by an expanded prescribing authority that is being granted to health professionals who have not traditionally had this responsibility and training. This discussion emphasizes the points that (a) the technology is available to share the best teaching materials for clinical pharmacology over the Internet, (b) clinical pharmacology organizations are best positioned to facilitate this exchange of educational materials, and that (c) continued discourse about problem-based learning and other curricular approaches to teaching clinical pharmacology is essential. The currently available information on the Internet includes case studies, slide sharing for lectures, educational programs and educational software. Clinical pharmacology organizations are not only starting to organize this information, but also to review the content of these programs and continuously add new material. These organizations have also developed a powerful tool through their journals in which to present educational series on rational therapeutics and to discuss educational approaches to instruction. Teaching forums, such as those presented annually at the American College of Clinical Pharmacology Annual Meeting, are essential to encourage discussion about teaching clinical pharmacology in the broadest context of the therapeutics, the economics and the legal aspects of clinical drug use.
Radiology departments are besieged with a multitude of information systems, each needing significant technical support. Information systems include the dictation system, the radiology information system (RIS), the picture archiving and communication systems (PACS), and every workstation and acquisition modality along with any dedicated system such as a teleradiology solution or specialized reporting tools. Typical radiology departments have very limited resources available to provide support. The challenges facing technical support are in responding to mission critical applications during a failure, building a knowledge base for each system, and providing clear communication with the users of the system experiencing problems. We have constructed a web-based support method that addresses the 3 main challenges of supporting so many different information systems with a formalized response mechanism. The website allows anyone to easily submit issues by describing the problem and selecting a specific category. Each support person subscribes to categories for which they are qualified. High-priority issues will be sent automatically to the alphanumeric pagers of the support personnel with the description of the problem. Drill down capabilities on the website allow searching of resolved and unresolved problems. Automatic emails are sent out to the person submitting the problem every time an action is taken to keep them in a closed loop. This tool pools the limited resources of the department and formalizes response mechanism to provide optimal support to the users.