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PubMed · 1090304

Steffimycin B, a DNA binding agent.

F Reusser
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Abstract

The antibiotic steffimycin B binds to double-stranded DNA as evidenced by difference spectroscopy and an increase of the thermal stability of DNA in the presence of the antibiotic. Salmon sperm DNA-steffimycin B complexes show a drastic decrease in template activity for Escherichia coli DNA polymerase I but not for DNA-idrected RNA polymerase. The differences in template properties of poly[d(A-T)] and poly (dG) - poly(dC)-antibiotic complexes,respectively, for DNA polymerase I and RNA polymerase suggest that the antibiotic interacts primarily with adenine or thymine bases or both in double-stranded DNA.

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AnimalsAnthracyclinesAnthraquinonesAnti-Bacterial AgentsDNADNA NucleotidyltransferasesDNA ReplicationDNA-Directed RNA PolymerasesDrug StabilityEscherichia coliGlycosidesMalePolynucleotidesSalmonSpermatozoaTemplates, GeneticTranscription, GeneticJournal Article

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F Reusser. 1975-03-21. Steffimycin B, a DNA binding agent.. https://doi.org/10.1016/0005-2787(75)90055-6

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