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PubMed · 10939951

RNA structure. Ribozyme evolution at the crossroads.

G F Joyce
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Abstract

Molecules that have similar sequences usually adopt the same structures and have the same functions. In his Perspective, Joyce explains that this is not always the case. In a remarkable study (Schultes and Bartel), an RNA sequence has been designed that can adopt two different structures, each with a different catalytic function. Joyce details how this study sheds light on the evolution of enzymes.

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Base PairingBase SequenceCatalysisEvolution, MolecularHepatitis Delta VirusMutationNucleic Acid ConformationRNA, CatalyticNASA Discipline ExobiologyNon-NASA CenterCommentJournal Article

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G F Joyce. 2000-07-21. RNA structure. Ribozyme evolution at the crossroads.. https://doi.org/10.1126/science.289.5478.401

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