Structure. Rhodopsin sees the light.

H R Bourne; E C Meng

doi:10.1126/science.289.5480.733

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PubMed · 10950717

Structure. Rhodopsin sees the light.

H R Bourne·E C Meng

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Abstract

Members of the seven transmembrane receptor superfamily bind a remarkable variety of ligands, from neurotransmitters to odorants, and activate a spectacular array of G protein signaling molecules. These G-protein coupled receptors (GPCRs) are important in many cellular functions and so there has been great interest in elucidating how they transmit their signals to the interior of the cell after activation by ligand. As Bourne and Meng explain in their Perspective, the molecular movements of activated GPCRs are becoming clear now that the first crystal structure of a GPCR (rhodopsin, the light-trapping receptor found in the retina of the eye) has been reported (Palczweski et al.).

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Binding Sites Crystallography, X-Ray Evolution, Molecular Heterotrimeric GTP-Binding Proteins Ligands Lipid Bilayers Models, Molecular Protein Structure, Secondary Receptors, Cell Surface Retinaldehyde Rhodopsin Stereoisomerism Vision, Ocular Comment Journal Article

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H R Bourne, E C Meng. 2000-08-04. Structure. Rhodopsin sees the light.. https://doi.org/10.1126/science.289.5480.733

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