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PubMed · 1097542

The epidermal-dermal junction.

R A Briggaman·C E Wheeler
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Abstract

Ultrastructurally, the epidermal-dermal junction is composed of four component areas:(1) the basal cell plasma membrane with its specialized attachment devices or hemidesmosomes, (2) an electron-lucent area, the lamina lucida, (3) the basal lamina, and (4) the sub-basal lamina fibrous components, including anchoring fibrils, dermal microfibril bundles, and collagen fibers. The light microscopic "basement membrane" comprises only the sub-basal lamina fibrous zone. Other cell types, including melanocytes and Merkel cells, are also found at the epidermal-dermal junction. Structures at the junction derive their origin from the epidermis and dermis: the basal lamina is primarily of epidermal origin, the anchoring fibrils of dermal origin. The junction serves the following functions: (1) epidermal-dermal adherence, (2) mechanical support for the epidermis, and (3) a barrier to the exchange of cells and of some large molecules across the junction.

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AnimalsBasement MembraneCell AdhesionCell AggregationCell DifferentiationCell MembraneCell MovementChick EmbryoCollagenDesmosomesFluorescent Antibody TechniqueHumansImmunoglobulinsLupus Erythematosus, SystemicMelanocytesMembrane PotentialsPemphigusReceptors, Antigen, B-CellSkinSkin Physiological PhenomenaJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R A Briggaman, C E Wheeler. 1975. The epidermal-dermal junction.. https://doi.org/10.1111/1523-1747.ep12598050

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