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Effects of the neuropeptide DG-AVP on morphine and food self-administration by dependent rhesus monkey.

N K Mello·J H Mendelson
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Abstract

Pretreatment with the neuropeptide DG-AVP (desglycrinamide9-arginine8-vasopressin) at two dose levels (25 and 125 mcg/kg) did not reduce intravenous morphine self-administration (0.25 mg/kg/inj) by morpine dependent monkeys, in comparison to pretreatment with saline or DG-AVP vehicle placebo. Food self-administration was also unaffected by DG-AVP pretreatment in comparison to control conditions. These data do not confirm previous reports of a dose-dependent suppression of heroin self-administration in rat following DG-AVP pretreatment [14].

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AnimalsArginine VasopressinFeeding BehaviorHaplorhiniHumansMaleMorphineMorphine DependenceSelf AdministrationJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

N K Mello, J H Mendelson. 1979. Effects of the neuropeptide DG-AVP on morphine and food self-administration by dependent rhesus monkey.. https://doi.org/10.1016/0091-3057(79)90206-5

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