Prostaglandin E2 on the electroencephalogram.

J J Amy; M Dierick; M Thiery; A Remouchamps

doi:10.1016/0090-6980(75)90121-5

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PubMed · 1105691

Prostaglandin E2 on the electroencephalogram.

J J Amy·M Dierick·M Thiery·A Remouchamps

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Abstract

Present study was prompted by the report from another center on the occasional occurrence of convulsions and abnormal electroencephalogram (E.E.G.) patterns in women aborted with intra-amniotic prostaglandin F2alpha (PGF2alpha). Fifty four subjects were investigated by means of an E.E.G. taken before and after initiation of PGE2 administration. They included pregnant and non-pregnant patients, nearly half (23) of whom were known epileptics. One seizure was observed during PG administration in a man with daily psychomotor attacks who had not taken his anticonvulsants on the day the test was performed. PGE2 caused no alteration of the E.E.G. in subjects with a normal control tracing; in those with an abnormal E.E.G., a deterioration was seen in one and an improvement in three. It is concluded that PGE2 is not epileptogenic at doses required for termination of pregnancy.

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Abortion, Induced Adult Amnion Cerebral Cortex Clinical Trials as Topic Electroencephalography Epilepsy Female Humans Injections Injections, Intravenous Male Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Prostaglandins E Uterus Clinical Trial Journal Article

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J J Amy, M Dierick, M Thiery, A Remouchamps. 1975. Prostaglandin E2 on the electroencephalogram.. https://doi.org/10.1016/0090-6980(75)90121-5

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