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Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method.

P Giunchedi·E Gavini·G Bonacucina·G F Palmieri
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Abstract

An emulsification-spray drying technique is used to prepare poly(D,L-lactic acid) (PDLLA) microparticles loaded with a water soluble, non-steroidal anti-inflammatory drug (NSAID), sodium naproxen (NaNPX). The method involves the preparation of a w/o emulsion in which the water soluble drug is dissolved in the aqueous dispersed phase, while the polymer is dissolved in the organic continuous phase. As a comparison, microparticles were prepared by spraying a suspension of the drug into an organic solution of the polymer. The spray-dried particles were characterized using SEM, DSC, XRD and in vitro release tests. The spray-dried product was then compressed (direct compression) to obtain controlled release matrix tablets. All microparticles release NaNPX within 30 min. The matrix tablets release the drug in 8-10 h; the matrix tablets characterized by the presence of surfactant (due to the emulsion used to obtain the microparticles) have the highest release rate.

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Anti-Inflammatory Agents, Non-SteroidalBiocompatible MaterialsCapsulesDelayed-Action PreparationsDrug CompoundingEmulsionsHumansIn Vitro TechniquesMicroscopy, Electron, ScanningMicrospheresNaproxenPolyestersTabletsJournal Article

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P Giunchedi, E Gavini, G Bonacucina, G F Palmieri. Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method.. https://doi.org/10.1080/02652040050161701

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