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Runt and Lozenge function in Drosophila development.

J Canon·U Banerjee
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Abstract

Runt and Lozenge (LZ) are members of the Runt domain family of transcriptional regulators and control a large number of developmental processes in Drosophila. Runt is a pair-rule gene, and is part of the network of genes that control pattern formation in the embryo. In the central nervous system, Runt function is necessary for the development of a subset of neurons. Runt is also a key regulator of sex determination, and directly controls Sex-lethal, a master gene that determines sex of the animal and controls dosage compensation. The LZ protein also participates in several key processes. LZ controls pre-patterning and cell-fate choices in the development of the visual system by regulating the expression of several fate-specifying transcription factors, and works in conjunction with general signaling pathways. LZ function is also required in hematopoiesis for the specification of a Drosophila blood cell lineage.

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AnimalsBody PatterningDNA-Binding ProteinsDrosophila ProteinsDrosophila melanogasterEyeFemaleGene Expression Regulation, DevelopmentalMaleNuclear ProteinsSex Determination ProcessesTranscription FactorsTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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J Canon, U Banerjee. 2000. Runt and Lozenge function in Drosophila development.. https://doi.org/10.1006/scdb.2000.0185

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