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PubMed · 11106806

Single molecule force spectroscopy in biology using the atomic force microscope.

J Zlatanova·S M Lindsay·S H Leuba
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Abstract

The importance of forces in biology has been recognized for quite a while but only in the past decade have we acquired instrumentation and methodology to directly measure interactive forces at the level of single biological macromolecules and/or their complexes. This review focuses on force measurements performed with the atomic force microscope. A general introduction to the principle of action is followed by review of the types of interactions being studied, describing the main results and discussing the biological implications.

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BiophysicsCell AdhesionDNAElasticityMicroscopy, Atomic ForcePolysaccharidesProteinsSignal Processing, Computer-AssistedViscosityJournal ArticleReview

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J Zlatanova, S M Lindsay, S H Leuba. 2000. Single molecule force spectroscopy in biology using the atomic force microscope.. https://doi.org/10.1016/s0079-6107(00)00014-6

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