PubMed · 11112244
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C P van der Smagt. Some gaps cannot be bridged.. https://doi.org/10.1001/archinte.160.22.3495
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This review is an evidence- and experience-based approach to the management of SLE, particularly its kidney manifestations. Specific protocols in substantial clinical detail are provided for management and monitoring, according to the severity of the SLE manifestations. The protocols are adapted from those used in a major SLE trial. The adaptations are based on subsequent extensive clinical use of these protocols. Also described is the concomitant use of cardio- and kidney-protective therapies to optimize patient outcomes.
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During the last seven years, the Cochrane Collaboration has rapidly developed into an important international organization, producing high quality systematic reviews of randomized trials. Challenges, which it will likely meet, include maintaining the quality of the reviews, ensuring that reviews are done of the most common therapies for important diseases, securing stable funding, and making the format of the reviews more accessible for the average clinician.