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PubMed · 11143670

Early intervention programme for infants with Down's syndrome.

S Katz
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Abstract

This article describes an early intervention programme for infants with Down's syndrome (DS) implemented by a registered nurse. The purpose of this programme was to help the families cope with the realities of raising a child with DS and help the infant fulfil his/her maximum potential. Small groups of three-four families with their infants met weekly with the nurse for 2-hour sessions. Each session was divided into two parts: exercises and discussion of issues relating to DS. Implications for nursing practice, education and management are discussed.

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Down SyndromeFamily NursingHumansInfantPediatric NursingJournal Article

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BibTeXRIS

S Katz. Early intervention programme for infants with Down's syndrome.. https://doi.org/10.12968/bjon.2000.9.8.6305

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Fasudil induces anti-inflammatory transcriptomic changes and increased proliferation in human trisomy 21 neural progenitor cells.

Down syndrome (DS) results from trisomy for human chromosome 21 and is the most frequent genetic cause of intellectual disability. No effective treatments currently exist that improve neurodevelopment and cognition. Atypical brain development in individuals with DS is apparent before birth, which suggests that the optimal time to begin administration of therapies is prenatally. Human neural progenitor cell (NPC) cultures provide a tractable in vitro model system to examine the effects of trisomy 21 (T21) on neurodevelopment and to measure the effects of pharmacological interventions. Here, we report the results of preclinical studies evaluating 24 candidate therapies. RNA sequencing analyses found that euploid and T21 NPCs showed different transcriptomic responses to five candidate pharmacotherapies. The Rho-associated coiled-coil kinase inhibitor fasudil increased proliferation of T21 NPCs, reduced expression of inflammatory pathway genes in T21 NPCs, and reduced markers of inflammation in LPS-stimulated microglial model systems. These results demonstrate that fasudil can alter multiple T21-associated abnormalities in a beneficial manner, suggesting that fasudil warrants further study as a candidate prenatal pharmacotherapy for DS.

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