PubMed · 11161920
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
A Farazaneh-Far. 2001. Aortic stiffness and calcification.. https://doi.org/10.1053/euhj.2000.2234
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
BACKGROUND: Atherosclerosis is a chronic inflammatory response of the arterial wall to injury. Macrophage migration inhibitory factor (MIF), a cytokine with potent inflammatory functions, was thus considered to be important in atherosclerotic lesion evolution. METHODS AND RESULTS: We studied the presence and distribution of MIF immunoreactivity (MIF-IR) and MIF mRNA in internal mammary arteries with a normal histology and arteries with plaques in different stages of human atherosclerosis. To address a potential role for the coactivator Jab1 as a cellular mediator of MIF effects in vascular tissue, we correlated the expression of MIF to that of Jab1 by using immunohistochemistry and coimmunoprecipitation. We further sought to determine a potential functional role for endothelium-derived MIF in early atherogenesis by studying the effects of oxidized LDL on MIF expression in cultured human umbilical vascular endothelial cells. The results showed that MIF-IR and Jab1-IR are found in all cell types present in atherosclerotic lesions, that MIF-IR is upregulated during progression of atherosclerosis, that MIF is produced locally in the arterial wall, and that all MIF(+) cells are simultaneously Jab1(+). Coimmunoprecipitation experiments demonstrated in vivo complex formation between MIF and Jab1 in plaques. MIF expression in human umbilical vascular endothelial cells and a macrophage line was upregulated after stimulation with oxidized LDL. CONCLUSIONS: MIF is produced abundantly by various cells in all types of human atherosclerotic lesions and thus may play an important role in early plaque development and advanced complicated lesions. MIF-Jab1 complexes could serve critical regulatory functions in atherosclerotic lesion evolution.
There are few reports in the literature on the ultrasound appearance of aortic saddle embolus, and none relating to small children. This unusual condition is usually diagnosed angiographically. The purpose of this report is to show how effectively high-frequency ultrasound can identify a saddle embolus with its associated collateral circulation in a young child, and to demonstrate its usefulness in monitoring the efficacy of treatment. In this case the embolus occurred as a complication of parvovirus B19 myocarditis and was diagnosed and followed up entirely by ultrasound examination, with no invasive procedure performed. The early development of an extensive collateral circulation prevented distal tissue necrosis and allowed a conservative approach to management.
Explore the source record for details and available documents.