Work and productivity loss in the rizatriptan multiple attack study.

E J Dasbach; G W Carides; W C Gerth; N C Santanello; J G Pigeon; Kramer

doi:10.1046/j.1468-2982.2000.00126.x

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Work and productivity loss in the rizatriptan multiple attack study.

E J Dasbach·G W Carides·W C Gerth·N C Santanello·J G Pigeon·Kramer

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Abstract

The objective of this study was to measure the self-reported effect of acute migraine and its treatment on paid work and productivity loss. Patients self-administered a questionnaire in which the impact of a recent migraine on paid work and productivity activities was assessed. We included the questionnaire in a randomized, double-blind, placebo-controlled, crossover, out-patient study designed to examine the safety and efficacy of rizatriptan (5-HT1B/1D receptor agonist) 10 mg p.o. in patients treating four separate migraine attacks. A total of 407 patients, aged 18-65 years, suffering from moderate to severe migrainous headaches was studied. Patients receiving rizatriptan compared with placebo reported 0.7 fewer hours (P < 0.01) of paid worked missed due to absenteeism, 0.4 fewer hours (P < 0.05) of productive time lost on the job, and 1.1 fewer total hours (P < 0.01) of work loss per migraine attack. Rizatriptan compared with placebo significantly reduced migraine-related work loss associated with absenteeism and decreased effectiveness on the job.

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Absenteeism Adult Efficiency Female Humans Male Middle Aged Migraine Disorders Multicenter Studies as Topic Randomized Controlled Trials as Topic Serotonin Receptor Agonists Surveys and Questionnaires Triazoles Tryptamines Work Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

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E J Dasbach, G W Carides, W C Gerth, N C Santanello, J G Pigeon, Kramer. 2000. Work and productivity loss in the rizatriptan multiple attack study.. https://doi.org/10.1046/j.1468-2982.2000.00126.x

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