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PubMed · 11218144

Miniaturized solid-phase extraction with resin disks.

J S Fritz·J J Masso
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Abstract

The properties and advantages of membrane disks for solid-phase extraction (SPE) are described. Miniaturization is a trend in SPE, as well as chemical analysis in general. A semimicro method is reviewed in which an extraction disk 4 mm in diameter is used for SPE. Even smaller scale separations are possible with a device in which a membrane 0.7 mm in diameter was incorporated into the needle of a 50-micro syringe. Aqueous samples containing 10 ppb of eight substituted benzenes were passed through the miniaturized-SPE syringe automatically using a single-syringe infusion pump. Elution volumes of 5 microl provided 500-fold concentrations and delivered average recoveries greater than 90% and an average relative standard deviation (RSD) of 4.6% for the analytes. Direct injection of the 5 microl eluate from the miniaturized-SPE syringe into a gas chromatograph also produced average recoveries greater than 90% and an average RSD of 6.2%.

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Benzene DerivativesChemistry Techniques, AnalyticalChromatography, GasChromatography, LiquidMiniaturizationResins, PlantJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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J S Fritz, J J Masso. 2001-02-09. Miniaturized solid-phase extraction with resin disks.. https://doi.org/10.1016/s0021-9673(00)01014-1

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Benzene Derivatives↗
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