PubMed · 11233545
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G J Ensing, H H Knight. 2001. 99Tc(m)-MAG3: problems with radiochemical purity testing.. https://doi.org/10.1097/00006231-200101000-00017
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The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.
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