PubMed Health⌕ Search

PubMed · 11317755

Automatic skeleton generation for visualizing 3D, time-dependent fluid flows: application to the virtual aneurysm.

Abstract

Intracranial aneurysms are the primary cause of non-traumatic subarachnoid hemorrhage. Difficulties in identifying which aneurysms will grow and rupture arise because the physicians lack important anatomic and hemodynamic information. Through simulation, this data can be captured, but visualization of large simulated data sets becomes cumbersome, often resulting in visual clutter and ambiguity. To address these visualization issues, we developed an algorithm that extracts a skeleton of the patterns in 3D, time-dependent blood flow. The algorithm decomposes the blood flow into "bare-bones" components that can be visualized individually or superimposed together to formulate an understanding of the flow patterns in the aneurysm.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D Lee, D J Valentino, G R Duckwiler, W J Karplus. 2001. Automatic skeleton generation for visualizing 3D, time-dependent fluid flows: application to the virtual aneurysm.. https://pubmed.ncbi.nlm.nih.gov/11317755/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Perfusion-based high-resolution functional imaging in the human brain at 7 Tesla.

Perfusion-based MRI measures cerebral blood flow (CBF) at the capillary level and can be used for functional studies based on the tight spatial coupling between brain activity and blood flow. Obtaining functional CBF maps with high spatial resolution is a major challenge because the CBF signal is intrinsically low and the SNR is critical. In the present work, CBF-based functional imaging was performed at a considerably smaller voxel size than previously reported in humans. High-resolution CBF maps were obtained with voxel sizes as small as 0.9 x 0.9 x 1.5 mm(3) in the human brain. High sensitivity was made possible by signal-to-noise gains at the high magnetic field of 7 T and by using a novel RF combination coil design. In addition, a reduction of the field-of-view was critical to achieve 0.9-mm in-plane resolution with gradient-echo echo-planar imaging in a single shot. Functional CBF data were compared with functional BOLD data to reveal that, for CBF, large contrast- to-noise gains were obtained at high spatial resolution, indicating that the functional CBF response was more localized. High-resolution functional CBF imaging is significant for neuroscience research because it provides better localization and more specific information than BOLD for monitoring brain function.

Cerebrovascular Circulation↗