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[Apolipoprotein E polymorphism and coronary disease].

R Peña·J M Mostaza·C Lahoz·J Jiménez·E Subirats·X Pinto·M Taboada·López-Pastor A·del Estudio RAP g
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Abstract

BACKGROUND: Apolipoprotein E (Apo E) plays an important role in atherogenesis. Apo E is polymorphic with three codominant alleles: *2, *3 and *4. Inthis study we evaluated the association between *4 allele and coronary heart disease in hypercholesterolemic subjects from Spain. SUBJECTS AND METHOD: We selected 389 subjects (56% women, mean age 57 years) with hypercholesterolemia who had been on a 6-weeks low fat, low cholesterol diet. Measurement of lipid and lipoprotein concentrations and determination of apoE genotype were carried out in a centralized laboratory. RESULTS: ApoE distribution was as follows: *2/*33%, *3/*3 75%, *3/*4 20%, *4/*4 1% and *2/*41%. Subjects were grouped into *4 (n = 83) or no *4 (n = 303) according to the presence or absence of the *4 allele. Three *2/*4 cases were excluded. Prevalence of coronary artery disease was 15.7% in *4 and 6.9% in no *4 (OR 2.49, 95% CI 1.19-5.22). The relationship persisted significant after correction for age, sex, cardiovascular risk factors and serum concentrations of total cholesterol, HDL-cholesterol and triglycerides by multiple logistic regression analysis (OR2.56, 95% CI 1.03-6.39).Conclusión:In Spain, *4 carriers have a higher prevalence of coronary artery disease than no analysis *4 carriers.

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Apolipoproteins ECoronary DiseaseFemaleHumansHypercholesterolemiaMaleMiddle AgedPolymorphism, GeneticEnglish AbstractJournal Article

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R Peña, J M Mostaza, C Lahoz, J Jiménez, E Subirats, X Pinto, M Taboada, López-Pastor A, del Estudio RAP g. 2001-05-19. [Apolipoprotein E polymorphism and coronary disease].. https://doi.org/10.1016/s0025-7753(01)71952-5

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