Lead compounds discovered from libraries.

A Golebiowski; S R Klopfenstein; D E Portlock

doi:10.1016/s1367-5931(00)00203-9

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PubMed · 11479119

Lead compounds discovered from libraries.

A Golebiowski·S R Klopfenstein·D E Portlock

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Abstract

Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.

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Combinatorial Chemistry Techniques Drug Design Proteins Journal Article Review

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A Golebiowski, S R Klopfenstein, D E Portlock. 2001. Lead compounds discovered from libraries.. https://doi.org/10.1016/s1367-5931(00)00203-9

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