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PubMed · 11479583

To bind or not to bind.

M D Biggin
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Abstract

Gene expression is regulated by transcription factors binding selectively to particular portions of the genome. To what extent are these protein-DNA interactions influenced by the intrinsic sequence-specific recognition properties at each protein, and to what extent are they affected by other factors, such as chromatin structure or cooperative interactions with other proteins. Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers.

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AnimalsChromatinCross-Linking ReagentsDNADrosophilaGene Expression RegulationHumansProtein BindingSaccharomyces cerevisiaeSubstrate SpecificityTranscription FactorsTranscription, GeneticUltraviolet RaysNewsComment

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M D Biggin. 2001. To bind or not to bind.. https://doi.org/10.1038/91045

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