Computer simulation study of hexokinase II from Ehrlich ascites cells.

L Garfinkel

doi:10.1111/j.1432-1033.1975.tb03943.x

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PubMed · 1149737

Computer simulation study of hexokinase II from Ehrlich ascites cells.

L Garfinkel

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Abstract

A study of the mechanism of hexokinase II from ascites cells the effects of its binding to mitochondrial membranes has been carried out by computer simulation. This is based on experimental data of Kosow and Rose and of Gumaa and McLean, and the theoretical methods of cleveland. For the soluble enzyme the mechanism is random with ternary produce-inhibition complexes; when bound to mitochondria, the mechanism becomes ordered-on, random-off, as the binding of ATP to the free enzymes becomes negligibly slow. The requirements of experimental data for mechanistic studies are discussed.

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Adenosine Triphosphate Animals Binding Sites Carcinoma, Ehrlich Tumor Computers Glucose Hexokinase Kinetics Mathematics Membranes Mice Mitochondria Models, Biological Protein Binding Journal Article Research Support, U.S. Gov't, P.H.S.

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L Garfinkel. 1975-02-21. Computer simulation study of hexokinase II from Ehrlich ascites cells.. https://doi.org/10.1111/j.1432-1033.1975.tb03943.x

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