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Methamphetamine effects on cognitive processing during extended wakefulness.

D A Wiegmann·R R Stanny·D L McKay·D F Neri·A H McCardie
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Abstract

We examined the effects of both 5- and 10-mg/7O kg body weight of d-methamphetamine HCl on high event rate vigilance and tracking performance in a 13.5-hr sustained-performance session during one night of sleep loss. At 0116 hours participants were administered either a 5 mg/70 kg oral dose of d-methamphetamine (n=10), 10 mg/70 kg d-methamphetamine (n=10), or a placebo (n=10) using standard double-blind procedures. Performance on all measures degraded markedly during the night in the placebo group. Both the 5- and 10-mg methamphetamines treatment reversed an initial decline in d', and reversed increases in nonresponses (lapses) and tracking error within approximately 3 hr of administration. No evidence that amphetamine treatment increased impulsive responding (fast guesses) was observed. The magnitude of the performance effects of the methamphetamine treatments was similar at 3 hr postadministration. However, the effects of the 5-mg dose were shorter-lived, disappearing by the last testing session (6.5 hr postadministration), whereas effects of the 10-mg dose tended to remain throughout testing. Both amphetamine treatments decreased subjective sleepiness during the night and tended to increase subjective sleep latencies during a post-testing sleep period.

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AdultArousalAttentionAwarenessCognitionDose-Response Relationship, DrugFatigueHumansMaleMemoryMethamphetamineMilitary PersonnelReaction TimeSleep DeprivationTask Performance and AnalysisTime FactorsUnited StatesWakefulnessClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, U.S. Gov't, Non-P.H.S.

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D A Wiegmann, R R Stanny, D L McKay, D F Neri, A H McCardie. 1996. Methamphetamine effects on cognitive processing during extended wakefulness.. https://doi.org/10.1207/s15327108ijap0604_5

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