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PubMed · 11551175

Review: proteins with repeated sequence--structural prediction and modeling.

A V Kajava
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Abstract

The relationship between the amino acid sequence and the three-dimensional structure of proteins with internal repeats is discussed. In particular, correlations between the amino acid composition and the ability to fold in a unique structure, as well as classification of the structures based on their repeat length, are described. This analysis suggests rules that can be used for the structural prediction of repeat-containing proteins. The paper is focused on prediction and modeling of solenoid-like proteins with the repeat length ranging between 5 and 40 residues. The models of leucine-rich repeat proteins and bacterial proteins with pentapeptide repeats are examined in light of the recently solved structures of the related molecules.

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AnimalsHumansModels, MolecularMolecular Sequence DataProtein Structure, SecondaryProteinsRepetitive Sequences, Amino AcidJournal ArticleReview

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BibTeXRIS

A V Kajava. Review: proteins with repeated sequence--structural prediction and modeling.. https://doi.org/10.1006/jsbi.2000.4328

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