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PubMed · 11580886

Qs in the nucleus.

H T Orr
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Abstract

The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating SCA7-induced retinal degeneration to a disruption of the photoreceptor-specific transcription factor CRX.

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AnimalsAtaxin-7Cell NucleusDisease Models, AnimalEye ProteinsHomeodomain ProteinsHumansMacromolecular SubstancesMiceMice, TransgenicMinisatellite RepeatsNerve Tissue ProteinsNeurodegenerative DiseasesNuclear ProteinsPeptidesPhotoreceptor Cells, VertebrateProtein BindingRetinal DegenerationSpinocerebellar AtaxiasTrans-ActivatorsTranscription FactorsTranscriptional ActivationTrinucleotide RepeatsCommentJournal Article

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H T Orr. 2001-09-27. Qs in the nucleus.. https://doi.org/10.1016/s0896-6273(01)00435-4

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