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PubMed · 11624525

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Abstract

The authors are investigated the life and all activity of the man of note since the time of Bulgarian National Renaissance. He graduate Medical Faculty in Bucurest and establish contacts with g.s. Rakovsky, Vasil Levsky and others Bulgarian revolutionary. After his back in Bulgaria he was physician in the town Stara Zagora and Sliven. N. Planinsky, bishop Seraphim, D-r Geogry Mirovich and other create the first society of the Red Cross. With co-operation of P.R. Slaveikov, publish the first Bulgarian newspaper in Sliven "Bulgarian flag". His public activity was illuminate as like as people "representative and functionary of the United".

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BibTeXRIS

M Todorova, I Triphonov. [Not Available].. https://pubmed.ncbi.nlm.nih.gov/11624525/

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Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria.

BACKGROUND: The gene encoding the dystrobrevin binding protein (DTNBP1) has been implicated in the pathogenesis of schizophrenia by several association studies. We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47). METHODS: We genotyped eight single nucleotide polymorphisms within the gene, four of which had been reported in previous studies, and four identified as informative by our group through direct screening of the gene and genotyping in a sample of cases and control subjects. RESULTS: A significant excess of transmissions was observed for two of the markers, p1635 and p1757, (p =.0009 and.0013, respectively). Analysis of two-, three-, and four-marker haplotypes produced numerous positive results, with six (4% of the total combinations) at p <.001. CONCLUSIONS: These results provide strong support for DTNBP1 as a susceptibility gene for schizophrenia; however, different haplotypes seem to be associated in different studies.

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