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PubMed · 11636533

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J Eskenazi
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Abstract

Based on hardly accessible archive documents as well as other original sources and literature data, the author traces the life of the Russian physician K. Yuriev, and more particularly the years of his sojourn in Bulgaria. The emigrant-populist has merits towards Bulgarian surgery in the period of antisepsis. Dr. Yuriev was in contact with the leftists of the liberal party, led by Zahari Stoyanov, he was in charge of the Russe revolutionary circle "1st March", a good friend to the well known Bulgarian populist Spiro Gulabchev and to the outstanding Bulgarian physician Dr. Paraskev Stoyanov.

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BulgariaGeneral SurgeryHistory, 19th CenturyPoliticsRussiaBiographyHistorical ArticleJournal ArticlePortrait

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BibTeXRIS

J Eskenazi. 1970. [Not Available].. https://pubmed.ncbi.nlm.nih.gov/11636533/

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IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.

It has been hypothesized that insulin-like growth factors (IGFs) and components of the growth-hormone (GH)-IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH-IGF system--the IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein-3 (IGFBP3). The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in IGF1 nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia.

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