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Palatal development in Twirler mice.

S G Gong·R L Eulenberg
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Abstract

OBJECTIVE: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted. RESULTS AND CONCLUSIONS: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models.

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AnimalsCephalometryCleft PalateColoring AgentsDisease Models, AnimalEmbryo, MammalianEmbryonic and Fetal DevelopmentEosine Yellowish-(YS)Fluorescent DyesGestational AgeHematoxylinHomozygoteImage Processing, Computer-AssistedMiceMice, Mutant StrainsPalateSkullStatistics as TopicComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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S G Gong, R L Eulenberg. 2001. Palatal development in Twirler mice.. https://doi.org/10.1597/1545-1569_2001_038_0622_pditm_2.0.co_2

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