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Antidepressants do not modulate estrogen receptor alpha-mediated gene expression.

B Hermann·I Vollmer·F Holsboer·R Rupprecht
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Abstract

The estrogen receptor alpha has been shown to be activated both in a ligand-dependent and in a ligand independent fashion. We investigated whether antidepressants may directly activate the estrogen receptor alpha or enhance ligand-dependent or ligand-independent activation of the estrogen receptor alpha. Whereas both ligand-dependent and ligand-independent activation of the estrogen receptor alpha could be demonstrated in transient transfection studies, antidepressants neither directly activated the estrogen receptor alpha nor did they enhance ligand-dependent or ligand-independent activation. Thus, there are differences between the glucocorticoid receptor and the estrogen receptor alpha with regard to ligand-independent activation and action of antidepressants.

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AnimalsAntidepressive AgentsAntidepressive Agents, TricyclicCell LineDesipramineDose-Response Relationship, DrugEstradiolEstrogen Receptor alphaGene Expression RegulationGenes, ReporterHaplorhiniHumansImipramineRatsReceptors, EstrogenTumor Cells, CulturedJournal ArticleResearch Support, Non-U.S. Gov't

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B Hermann, I Vollmer, F Holsboer, R Rupprecht. 2001. Antidepressants do not modulate estrogen receptor alpha-mediated gene expression.. https://doi.org/10.1007/s007020170009

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