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Effect of ovariectomy on oestrogen-sensitive feedback elements.

M Zanisi·L Martini
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Abstract

Serum LH and FSH were determined by radioimmunoassay in untreated and oestrogen-treated ovariectomized rats. The animals were sacrificed 7, 14, 21 and 28 days after ovariectomy. Oestradiol benzoate was administered in the daily dose of 50 mug on the 2 days preceeding sacrifice. It has been found that oestrogens exert a strong inhibitory effect on the release of LH, as evidenced by a decrease in serum titers of the hormone. Oestradiol suppressed LH almost completely in animals with both low (7 or 14 days post-ovariectomy), and high levels of serum LH(21 or 28 days post-ovariectomy). Oestradiol failed to totally suppress serum FSH at any post-castration time considered. Moreover, the inhibitory effect of oestradiol on FSH release decreased as post-castration time increased. These data suggest that the feedback mechanisms which control the secretion of LH and those which control the secretion of FSH are substantially different.

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AnimalsCastrationDepression, ChemicalEstradiolFeedbackFemaleFollicle Stimulating HormoneLuteinizing HormoneOvaryRatsTime FactorsJournal Article

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M Zanisi, L Martini. 1975. Effect of ovariectomy on oestrogen-sensitive feedback elements.. https://doi.org/10.1530/acta.0.0780689

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