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PubMed · 1175548

Pulmonary response to polyurethane dust.

K L Stemmer·E Bingham·W Barkley
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Abstract

Weanling and 9 months or older rats were exposed to particles of an aged (PUF I) or freshly prepared (PUF II) rigid polyurethane foam by intratracheal intubation. The dose was 5 mg of particles. The response of the lung tissue was examined morphologically by serial sacrifices. Inflammation and macrophage activity were the initial responses. Fibrosis developed after 6 months. Nodular scars and perifocal emphysema were seen after 12 months. Four rats had a papillary adenoma in a major bronchus after 18 months exposure to PUF II.

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Age FactorsAnimalsBronchial NeoplasmsCystadenomaDustEnvironmental ExposureFemaleIntubation, IntratrachealLungLung DiseasesLung NeoplasmsLymphocytesMacrophagesMaleParticle SizePolyurethanesPulmonary EmphysemaPulmonary FibrosisRatsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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K L Stemmer, E Bingham, W Barkley. 1975. Pulmonary response to polyurethane dust.. https://doi.org/10.1289/ehp.7511109

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