Developing animal models for analyzing SERM activity.

J M Emmen; K S Korach

doi:10.1111/j.1749-6632.2001.tb04000.x

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PubMed · 11795377

Developing animal models for analyzing SERM activity.

J M Emmen·K S Korach

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Abstract

Estrogens have effects on many organ systems, beyond the reproductive system, in both females and males. Estrogen effects are exerted through specific receptors, of which there are two types: estrogen receptor (ER) alpha and estrogen receptor (ER) beta. To study the roles of each receptor in vivo, a series of mice were generated lacking either a functional ER alpha or ER beta or both. These mice, labeled alphaERKO, betaERKO, or alphabetaERKO, respectively, have been useful in defining the tissue specificities, localization, and functions of each of the estrogen receptors. These mouse models also show great promise for use in defining the effectiveness of putative SERMs.

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Animals Estrogen Receptor alpha Estrogen Receptor beta Female Kinetics Mammary Glands, Animal Mice Models, Animal Ovary Receptors, Estrogen Selective Estrogen Receptor Modulators Uterus Journal Article Review

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J M Emmen, K S Korach. 2001. Developing animal models for analyzing SERM activity.. https://doi.org/10.1111/j.1749-6632.2001.tb04000.x

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