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PubMed · 11795410

DOTS and DOTS-plus: not the only answer.

P Farmer
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Abstract

Multidrug-resistant tuberculosis is already a global pandemic, with focal "hot spots" of ongoing transmission. Although DOTS (directly observed treatment, short course) chemotherapy is the goal of global tuberculosis control, short-course chemotherapy will not cure multidrug-resistant tuberculosis. In settings of high transmission of multidrug-resistant tuberculosis, "DOTS plus" (a complementary DOTS-based strategy with provisions for treating multidrug-resistant tuberculosis) is warranted. DOTS-plus project implementation to date reveals important clinical, epidemiological, and economic lessons. Community-based strategies designed to enhance local capacity are cost effective and make it possible to meet new medical challenges.

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Antitubercular AgentsDrug Resistance, MultipleHumansPeruRussiaTuberculosis, Multidrug-ResistantJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P Farmer. 2001. DOTS and DOTS-plus: not the only answer.. https://doi.org/10.1111/j.1749-6632.2001.tb11375.x

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