Epigenetics as a first exit problem.

E Aurell; K Sneppen

doi:10.1103/physrevlett.88.048101

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Epigenetics as a first exit problem.

E Aurell·K Sneppen

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Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage. The formalism defines a quantitative measure of robustness of inherited states.

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Bacteriophage lambda Binding Sites DNA, Viral DNA-Binding Proteins Escherichia coli Gene Expression Regulation, Viral Lysogeny Models, Genetic Repressor Proteins Viral Proteins Viral Regulatory and Accessory Proteins Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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E Aurell, K Sneppen. 2002-01-08. Epigenetics as a first exit problem.. https://doi.org/10.1103/physrevlett.88.048101

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